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The last decade has seen a rapid surge of interest in new sensing and monitoring devices for healthcare and the use of wearable/wireless devices for clinical applications. One key development in this area is implantable in vivo monitoring and intervention devices. Several promising prototypes are emerging for managing patients with debilitating neurological disorders and for monitoring of patients with chronic cardiac diseases. Despite the technological developments of sensing and monitoring devices, issues related to system integration, sensor miniaturization, low-power sensor interface circuitry design, wireless telemetric links and signal processing have still to be investigated. Moreover, issues related to Quality of Service, security, multi-sensory data fusion, and decision support are active research topics.